Replication studies

Replication studies considered harmful

Context: There is growing interest in establishing software engineering as an evidence-based discipline. To that end, replication is often used to gain confidence in empirical findings, as opposed to reproduction where the goal is showing the correctness, or validity of the published results. Objective: To consider what is required for a replication study to confirm the original experiment and ...

Studies on the replication of African Horse Sickness Virus in two different cell line cultures

Studies on Prion Replication in Spleen

Some of the early events following scrapie infection take place in the lymphoreticular system (LRS) and result in significant replication of prions in lymphoid organs. The identity of the cells in the LRS that produce prions and their role in neuroinvasion are still unknown. We find that in the spleen of scrapie-infected mice, prions are associated with T and B cells and to a somewhat lesser de...

Quality and Replication of Microarray Studies

Quality assessment of DNA microarrays uses different spot parameters that contain complete information to describe each microarray and detect corrupted spots. Images obtained through replication should result in improved quality as measured according to parameters. We propose methods to determine the number of replicates required to achieve a certain level of quality, and present an application...

Power and replication in case-control studies.

The case-control study design, a common staple of epidemiology, is increasingly used to test for genetic association. The simplicity of the design accounts for both its appeal and its limitations. Too often, however, apparent controversy arises for lack of appreciation of basic tenets underlying statistical testing. Power and replication are two concepts most commonly ignored in evaluating such...